Semi-permanent, self-derived injectable fillers such Autologen and autologous fat offer augmentation options from your own body.  They can be used for wrinkles, and deep folds such as the nasolabial area (lines that run from nose to mouth) and the glabellar region (frown lines between the brows.  They are also used for augmentation of the lips and for filling out acne scars and other types of tissue deficiencies.  They can be utilized after a temporary try-on product has been used or used as a first time product for the above indications.  In this section, we will discuss the various options in soft tissue augmentation with the use of self-derived options.

These options are of your own body.  This means there is no chance of rejection and you have your own storage bank of options.  Be advised that natural "fillers" can be absorbed by your body resulting in decreased augmentation down the road.  Some surgeons incorporate newer techniques to increase the longevity but it is not an exact science although every body is different.
   

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Autologen: (technically: Autologous human collagen) This injectable collagen is derived from the patient's own skin which is removed at the time of a facelift, abdominoplasty, breast reduction, breast lift or other type of procedure involving tissue excision.  Your tissue was packaged in sterile solution and put on ice and sent to Collagenesis of Beverly, Massachusetts.  However, I believe this company has gone out of business.  Collagenesis filed Chapter 11 in the U.S. Bankruptcy Court in Boston (#19656).   The lab once processed the tissue, extracting the collagen, preserved it and kept it frozen in the special cryo-freezers at the lab.  Whenever you made an appt for a touch up, it was sent to your doctor's office whenever needed.  It is a rather expensive and time-consuming (4 to 6 weeks) process but there was no risk of rejection as it is your own collagen and less likely to reabsorb.  It was reported to be well tolerated when re-injected into the body.
Allergy Test: n/a
Longevity: 4 mo to 9 mo 
Cost: Approximately $1,200. - 4,000. for 3.0 cc

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Dermis Grafts: This procedure involves excising tissue, like after a face lift, abdominoplasty, breast reduction or lift, deepithelializing the graft by removing the epidermis, cleaning it, then rolling up and inserting it.  Some surgeons suture the ends of the graft so that it cannot unroll during insertion.
Allergy Test: not necessary as it is your own tissue
Longevity: unknown - it isn't supposed to absorb once vascularity takes place but it truly can vary. 
Cost: $2,000. - $3,000. approximately
Available in the United States? Yes

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Dermis Fat Grafts: This procedure involves excising tissue, like after a face lift, abdominoplasty, breast reduction or lift, deepithelializing the graft by removing the epidermis but leaving the fatty layer.  The graft is then cleaned and inserted.  This is more risky as I know of patients who have had fatty cysts afterwards and had to be aspirated, or excised and given a course of antibiotics.  Also the graft may twist and contract, distorting the lips. 
Allergy Test: not necessary as it is your own tissue
Longevity: unknown 
Cost: $2,000. - $3,000. approximately
Available in the United States? Yes

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Fascia Grafts: This procedure is performed by removing fascia, which is the thick white covering over muscles and some organs which keeps them compact and protected, usually from temporalis muscle. 
Allergy Test: not necessary as it is your own tissue
Longevity: Unknown, it isn't supposed to resorb once vascularity takes place but who knows. 
Cost: $2,000. - $3,000. approximately
Available in the United States? Yes

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Fat grafting, transfer or transplanting: This procedure is carried out by aspiration or manual excision, processed in-office and reinjected into your body.  The pluses?  It is your own fat and doesn't get rejected. The drawbacks are that many of the fat cells do not survive the procedure and die off being absorbed into the body if not performed correctly or if your metabolism is very high and the fact that your body does not normally store its excess fat in the lips. 

Some surgeons advise that 30% to 50% augmentation remains on average after 1 year due to the movement of the lips and if proper vascularization was not met.  Another downfall is that some surgeons may severely overcorrect the area with fat cells to compensate for the fat cell necrosis.  Unfortunately, over injection may actually kill the fat cells instead of helping them.  Other surgeons irrigate the fat cells with a serum of oxygenated saline laced with vitamins and/or your own plasma, or albumin and then fat is injected in intervals instead of all in one lump sum.  The fat cell survival rate may be better.  The technique of micro-droplets and using your body's plasma is proving to further the longevity of the injected fats.  Either micro-droplets are injected within 2 to 3 visits or a tube of your own blood is drawn right before the procedure where it will be spun in a special machine that is used to separate the plasma and this is injected along with your fat which has also been removed with a special cannula resulting in whole, less damaged fat cells.  This may give your treatment area a head start in creating new vascularity (new vessels) around and through the newly injected fat. 
Allergy Test: not necessary as it is your own fat
Longevity: Can last anywhere from 6 months to several years.  Yet, some doctors are claiming semi-permanency with the newer techniques.
Cost: about $2,400. - $4,500.
Available in the United States? Yes, quite everywhere, but the trick is finding a fat grafting specialist.
More Information:  See our Fat Grafting Section

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Isolagen: (technically: cultured human fibroblasts) Isolagen can be considered a self-derived catalyst so it falls under two categories, autologous and Bio-catalyst.  Reportedly, Isolagen is presently being run through the required clinical trials in the US.  Isolagen is comprised primarily of cultured human fibroblasts.  Fibroblasts are connective-tissue cells of mesenchymal origin that secrete proteins; especially molecular collagen from which the extracellular fibrillar matrix of connective tissue forms. Mesenchymal means: loosely organized undifferentiated mostly messodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone and cartilage. Messoderm (as in Messodermal) is the middle of the three primary germ layers of an embryo and is the source of many bodily tissues and structures.Broadly, tissues derived from this germ layer are considered Messodermic. 

Basically, Isolagen is an injectable cultured (grown in a petri dish, in a lab, from skin taken from YOUR body) product that, when injected into the body, encourages tissue growth for an undetermined amount of time.  The human fibroblasts are said not to cause any negative reaction and is extremely tolerated, rather, accepted wholeheartedly, by your body.  In addition to sparking actual tissue growth from the live fibroblast injection, the plus is that it is of your own body.
Allergy test: reportedly not necessary
Longevity: reportedly indefinite (forever) although the collagen is susceptible to natural aging.
Cost: unknown
Available in the United States? Isolagen has not been approved by the FDA for use in the US as of yet. Please read the above update.
Update! 11/02/00: I spoke with a representative/scientist with (Isolagen Technologies Inc, Paramus, NJ) and although they have completed "trials", reportedly the FDA wants them to do them all over in official FDA trials. However I was told the Isolagen should be available in Japan by January '01.
Update! 1/18/01: I received a letter from my contact who once worked with the company: 

"For most of 2000 and 2001 activity was focused on raising capital and the company came close to shutting down permanently. In August 2001 venture capital funded the company and did a reverse merger into a publicly traded company. It can be tracked under the symbol ISLG.OB. The new investors moved the company to Texas and my tenure with the company ended at this point. My guess is they are very close to getting FDA approval for starting the next clinical trials. There are only a few press releases out there at this point. However, I expect that will change as soon as they get the FDA ok to start the trials."

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Scar Tissue Grafting: This procedure requires the presence of a scar you would like removed. A thicker, ropey scar is best.  In this procedure, the scar is removed, cleansed, and re-implanted in your lips.  Of course if you don't have a large enough scar, you can't get this.  The bonus is that you get scar revision surgery and bigger lips.
Allergy Test: not necessary as it is your own tissue
Longevity: Unknown, scar tissue isn't supposed to resorb but who knows. 
Cost: $2,000. - $3,000. approximately
Available in the United States? Yes

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Tendon Grafting: (technically: palmaris longis graft) This procedure is one of those I consider a little excessive.  It is performed by first removing a small tendon, called the palmaris longis tendon.  This tendon is located on the inside of your lower forearm, near the wrist.  Now, this tendon is not very deep within your arm and removing it will not interfere with the mobility or function of your hand or wrist.  However, this particular tendon is utilized in the restoration of the hand should you injure your hand to a point of limited mobility.  It's kind of like an extra. So, if you can stand to part with this tendon and you are quite sure you will never need it then this is for you (I suggest using the tendon from your weaker arm as the probability of injuring your stronger arm is greater).  The standard tunnel is created within the lip and the tendon is then inserted and positioned and the incisions are sutured.  There is no chance of rejection as this is your tissue and it is considered natural and softer than synthetic implants or even AlloDerm. I find this next part bizarre but get this... Obviously some of us are evolving because quite a number of people are born without this particular tendon! Go figure! I would rather be without wisdom teeth or something.  This is a rare procedure as not all surgeons are willing to remove this tendon.  You do have to harvest this tendon and deal with the removal site healing as well. Besides what if it is resorbed??  All of that for nothing.
Allergy Test: n/a
Longevity: Reportedly permanent

Cost: $2,500. -  $4,000. 
Available in the United States? Yes, but rare.

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